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Hence, tamoxifen combines two favorable properties associated with compounds that elicit P-gp-dependent collateral sensitivity

It is modeled after a naturally occurring protein fragment found within gastric juice and has attracted considerable scientific attention for its involvement in regenerative and healing pathways

ROS can modulate the activity of various transcription factors and signaling pathways involved in immune cell activation, differentiation, and function

The harmful effect is counteracted by the existence of antioxidant systems, represented by molecules capable of neutralizing ROS, thus preventing the induction of oxidation damage (2,4)